|Application ||WB, E|
|Other Accession||Q4R6F6, NP_997545.2|
|Calculated MW||82876 Da|
|Antigen Region||401-429 aa|
|Other Names||Zinc finger CCCH domain-containing protein 14, Mammalian suppressor of tau pathology-2, MSUT-2, Renal carcinoma antigen NY-REN-37, ZC3H14|
|Target/Specificity||This ZC3H14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-429 amino acids from the Central region of human ZC3H14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZC3H14 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|
|Cellular Location||Nucleus speckle Isoform 3: Nucleus speckle.|
|Tissue Location||Isoform 1 and isoform 6 are expressed in fetal and adult brain. Isoform 1 and isoform 6 are expressed in fetal and adult temporal lobe.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).
Wheeler, J.M., et al. Biochem. Soc. Trans. 38(4):973-976(2010)
Leung, S.W., et al. Gene 439 (1-2), 71-78 (2009) :
Kelly, S.M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(30):12306-12311(2007)
Scanlan, M.J., et al. Int. J. Cancer 83(4):456-464(1999)
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