ZC3H14 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q6PJT7 |
Other Accession | Q4R6F6, NP_997545.2 |
Reactivity | Human |
Predicted | Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 82876 Da |
Antigen Region | 401-429 aa |
Gene ID | 79882 |
---|---|
Other Names | Zinc finger CCCH domain-containing protein 14, Mammalian suppressor of tau pathology-2, MSUT-2, Renal carcinoma antigen NY-REN-37, ZC3H14 |
Target/Specificity | This ZC3H14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-429 amino acids from the Central region of human ZC3H14. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZC3H14 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZC3H14 |
---|---|
Function | Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides. |
Cellular Location | Nucleus speckle Note=Colocalizes with poly(A) RNA in nuclear speckles {ECO:0000250|UniProtKB:Q7TMD5} [Isoform 3]: Nucleus speckle. |
Tissue Location | Isoform 1 and isoform 6 are expressed in fetal and adult brain. Isoform 1 and isoform 6 are expressed in fetal and adult temporal lobe. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).
References
Wheeler, J.M., et al. Biochem. Soc. Trans. 38(4):973-976(2010)
Leung, S.W., et al. Gene 439 (1-2), 71-78 (2009) :
Kelly, S.M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(30):12306-12311(2007)
Scanlan, M.J., et al. Int. J. Cancer 83(4):456-464(1999)
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