|Application ||WB, E|
|Calculated MW||70105 Da|
|Antigen Region||23-52 aa|
|Other Names||Acid-sensing ion channel 4, ASIC4, Amiloride-sensitive cation channel 4, Amiloride-sensitive cation channel 4, pituitary, ASIC4, ACCN4|
|Target/Specificity||This ACCN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the N-terminal region of human ACCN4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACCN4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms.
Donier, E., et al. Eur. J. Neurosci. 28(1):74-86(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Grunder, S., et al. Eur. J. Hum. Genet. 9(9):672-676(2001)
Grunder, S., et al. Neuroreport 11(8):1607-1611(2000)
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