|Application ||WB, E|
|Other Accession||Q810B8, NP_775101.1|
|Calculated MW||94331 Da|
|Antigen Region||748-777 aa|
|Other Names||SLIT and NTRK-like protein 4, SLITRK4|
|Target/Specificity||This SLITRK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 748-777 amino acids from the C-terminal region of human SLITRK4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLITRK4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Suppresses neurite outgrowth.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants.
Aruga, J., et al. Gene 315, 87-94 (2003) :
Aruga, J., et al. Mol. Cell. Neurosci. 24(1):117-129(2003)
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