|Application ||WB, E|
|Calculated MW||31914 Da|
|Antigen Region||88-117 aa|
|Other Names||Steroidogenic acute regulatory protein, mitochondrial, StAR, START domain-containing protein 1, StARD1, STAR, STARD1|
|Target/Specificity||This STAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human STAR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STAR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.|
|Tissue Location||Expressed in gonads, adrenal cortex and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Mizutani, T., et al. J. Biol. Chem. 285(36):28240-28251(2010)
Sahakitrungruang, T., et al. J. Clin. Endocrinol. Metab. 95(7):3352-3359(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
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