|Application ||WB, E|
|Other Accession||Q5BJQ5, P70425, NP_002921.1|
|Calculated MW||24668 Da|
|Antigen Region||41-69 aa|
|Other Names||GTP-binding protein Rit2, Ras-like protein expressed in neurons, Ras-like without CAAX protein 2, RIT2, RIN, ROC2|
|Target/Specificity||This RIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human RIT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RIT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds and exchanges GTP and GDP.|
|Cellular Location||Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane|
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Provided below are standard protocols that you may find useful for product applications.
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Glessner, J.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10584-10589(2010)
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Sonuga-Barke, E.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1359-1368 (2008) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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