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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SH3PXD2A Antibody (N-term)   

SH3PXD2A Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SH3PXD2A Antibody (N-term) AP16560a
    SH3PXD2A Antibody (N-term) (Cat. #AP16560a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SH3PXD2A antibody detected the SH3PXD2A protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5TCZ1
Other Accession O89032, NP_055446.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 125289 Da
Antigen Region 222-250 aa
Additional Information
Gene ID 9644
Other Names SH3 and PX domain-containing protein 2A, Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains, SH3PXD2A, FISH, KIAA0418, SH3MD1, TKS5
Target/Specificity This SH3PXD2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-250 amino acids from the N-terminal region of human SH3PXD2A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSH3PXD2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FISH, KIAA0418, SH3MD1, TKS5
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
Cellular Location Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells
Tissue Location Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas
Research Areas
Citations (0)

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SH3PXD2A is required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Laumet, G., et al. Neurosci. Lett. 468(1):1-2(2010)
Crimaldi, L., et al. Exp. Cell Res. 315(15):2581-2592(2009)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Gianni, D., et al. Sci Signal 2 (88), RA54 (2009) :

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$ 295.00
$ 99.00
Cat# AP16560a
(40 western blots)
Availability: In Stock
Bulk Size
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