|Application ||WB, E|
|Calculated MW||165743 Da|
|Antigen Region||869-897 aa|
|Other Names||Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D, Soluble scavenger protein with 5 SRCR domains, SSc5D, SSC5D|
|Target/Specificity||This SSC5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 869-897 amino acids from the Central region of human SSC5D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SSC5D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity).|
|Cellular Location||Secreted. Cytoplasm|
|Tissue Location||Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney.|
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Goncalves, C.M., et al. Mol. Immunol. 46(13):2585-2596(2009)
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