|Application ||WB, E|
|Calculated MW||126551 Da|
|Antigen Region||985-1013 aa|
|Other Names||FH1/FH2 domain-containing protein 1, Formin homolog overexpressed in spleen 1, FHOS, Formin homology 2 domain-containing protein 1, FHOD1, FHOS, FHOS1|
|Target/Specificity||This FHOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 985-1013 amino acids from the C-terminal region of human FHOD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FHOD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic|
|Tissue Location||Ubiquitous. Highly expressed in spleen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq].
Hannemann, S., et al. J. Biol. Chem. 283(41):27891-27903(2008)
Schulte, A., et al. Structure 16(9):1313-1323(2008)
Takeya, R., et al. EMBO J. 27(4):618-628(2008)
Schulte, A., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (PT 10), 878-881 (2007) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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