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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EPB49 Antibody (Center)   

EPB49 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EPB49 Antibody (Center) AP16598c
    EPB49 Antibody (Center) (Cat. #AP16598c) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the EPB49 antibody detected the EPB49 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08495
Other Accession Q9WV69, Q08DM1, NP_001107609.1, NP_001107608.1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 45514 Da
Antigen Region 249-277 aa
Additional Information
Gene ID 2039
Other Names Dematin, Dematin actin-binding protein, Erythrocyte membrane protein band 49, DMTN, DMT, EPB49
Target/Specificity This EPB49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 amino acids from the Central region of human EPB49.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEPB49 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DMT, EPB49
Function Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Cellular Location Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuol in malaria- infected erythrocytes at late stages of plasmodium berghei or falciparum development
Tissue Location Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney
Research Areas
Citations (0)

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Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]).


Vugmeyster, L., et al. J. Biomol. NMR 47(2):155-162(2010)
Chen, L., et al. Protein Sci. 18(3):629-636(2009)
Vugmeyster, L., et al. J. Biomol. NMR 43(1):39-50(2009)
Vermeulen, W., et al. J. Mol. Biol. 359(5):1277-1292(2006)
Frank, B.S., et al. J. Biol. Chem. 279(9):7909-7916(2004)

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$ 295.00
$ 99.00
Cat# AP16598c
(40 western blots)
Availability: In Stock
Bulk Size
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