|Application ||WB, E|
|Calculated MW||20363 Da|
|Antigen Region||29-58 aa|
|Other Names||Interferon-stimulated gene 20 kDa protein, Estrogen-regulated transcript 45 protein, Promyelocytic leukemia nuclear body-associated protein ISG20, ISG20, HEM45|
|Target/Specificity||This ISG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the Central region of human ISG20.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ISG20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body|
|Tissue Location||Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines|
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Provided below are standard protocols that you may find useful for product applications.
Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses.
Hao, Y., et al. J. Huazhong Univ. Sci. Technol. Med. Sci. 28(1):11-13(2008)
Horio, T., et al. FEBS Lett. 577 (1-2), 111-116 (2004) :
Espert, L., et al. J. Biol. Chem. 278(18):16151-16158(2003)
Izmailova, E., et al. Nat. Med. 9(2):191-197(2003)
Nguyen, L.H., et al. Biochemistry 40(24):7174-7179(2001)
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