- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||35110 Da|
|Antigen Region||76-105 aa|
|Other Names||Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2|
|Target/Specificity||This FAIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human FAIM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAIM2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0950, LFG, LFG2, NMP35, TMBIM2|
|Function||Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane|
|Tissue Location||Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.|
Provided below are standard protocols that you may find useful for product applications.
FAIM2 protects cells uniquely from Fas-induced apoptosis.
Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)
Bucan, V., et al. Cell. Mol. Biol. Lett. 15(2):296-310(2010)
Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010)
Li, S., et al. Am. J. Clin. Nutr. 91(1):184-190(2010)
Hotta, K., et al. J. Hum. Genet. 54(12):727-731(2009)
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