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DNALI1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14645 |
| Other Accession | Q4FZV3, Q8BVN8, Q4R3K5, NP_003453.2 |
| Reactivity | Human |
| Predicted | Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29662 Da |
| Antigen Region | 215-243 aa |
| Gene ID | 7802 |
|---|---|
| Other Names | Axonemal dynein light intermediate polypeptide 1, Inner dynein arm light chain, axonemal, hp28, DNALI1 |
| Target/Specificity | This DNALI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human DNALI1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DNALI1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNALI1 (HGNC:14353) |
|---|---|
| Function | Involved in sperm flagellum assembly. |
| Cellular Location | Cell projection, cilium. Cell projection, cilium, flagellum. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6GN86}. Cytoplasm |
| Tissue Location | Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis Expressed in spermatozoa and airway epithelial cells (at protein level) (PubMed:31178125). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Combs, J., et al. Proc. Natl. Acad. Sci. U.S.A. 103(40):14883-14888(2006)
Kastury, K., et al. J. Clin. Endocrinol. Metab. 82(9):3047-3053(1997)
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