|Application ||WB, E|
|Other Accession||Q4FZV3, Q8BVN8, Q4R3K5, NP_003453.2|
|Predicted||Monkey, Mouse, Rat|
|Calculated MW||29662 Da|
|Antigen Region||215-243 aa|
|Other Names||Axonemal dynein light intermediate polypeptide 1, Inner dynein arm light chain, axonemal, hp28, DNALI1|
|Target/Specificity||This DNALI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human DNALI1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNALI1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a dynamic role in flagellar motility.|
|Cellular Location||Cell projection, cilium|
|Tissue Location||Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Combs, J., et al. Proc. Natl. Acad. Sci. U.S.A. 103(40):14883-14888(2006)
Kastury, K., et al. J. Clin. Endocrinol. Metab. 82(9):3047-3053(1997)
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