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SOX8 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P57073 |
| Other Accession | NP_055402.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47314 Da |
| Antigen Region | 225-253 aa |
| Gene ID | 30812 |
|---|---|
| Other Names | Transcription factor SOX-8, SOX8 |
| Target/Specificity | This SOX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-253 amino acids from the Central region of human SOX8. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOX8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX8 {ECO:0000303|Ref.1, ECO:0000312|HGNC:HGNC:11203} |
|---|---|
| Function | Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
References
Nonaka, D. Am. J. Clin. Pathol. 131(5):731-736(2009)
Hoff, S., et al. J. Comp. Neurol. 509(4):356-371(2008)
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)
Schepers, G., et al. J. Biol. Chem. 278(30):28101-28108(2003)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
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