|Application ||WB, E|
|Calculated MW||34899 Da|
|Antigen Region||191-219 aa|
|Other Names||Sulfotransferase family cytosolic 1B member 1, ST1B1, Sulfotransferase 1B1, 282-, Sulfotransferase 1B2, ST1B2, Thyroid hormone sulfotransferase, SULT1B1, ST1B2, SULT1B2|
|Target/Specificity||This SULT1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of human SULT1B1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SULT1B1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.|
|Tissue Location||Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes.
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Allali-Hassani, A., et al. PLoS Biol. 5 (5), E97 (2007) :
Dombrovski, L., et al. Proteins 64(4):1091-1094(2006)
Meinl, W., et al. Biochem. Biophys. Res. Commun. 288(4):855-862(2001)
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