|Application ||WB, E|
|Calculated MW||60131 Da|
|Antigen Region||507-533 aa|
|Other Names||Copine-3, Copine III, CPNE3, CPN3, KIAA0636|
|Target/Specificity||This CPNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-533 amino acids from the C-terminal region of human CPNE3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPNE3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870) Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870)|
|Tissue Location||Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands.
Heinrich, C., et al. Oncogene 29(11):1598-1610(2010)
Thomas, G., et al. Nat. Genet. 40(3):310-315(2008)
Cowland, J.B., et al. J. Leukoc. Biol. 74(3):379-388(2003)
Caudell, E.G., et al. Biochemistry 39(42):13034-13043(2000)
Creutz, C.E., et al. J. Biol. Chem. 273(3):1393-1402(1998)
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