CPNE3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O75131 |
Other Accession | NP_003900.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 60131 Da |
Antigen Region | 507-533 aa |
Gene ID | 8895 |
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Other Names | Copine-3, Copine III, CPNE3, CPN3, KIAA0636 |
Target/Specificity | This CPNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-533 amino acids from the C-terminal region of human CPNE3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CPNE3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPNE3 (HGNC:2316) |
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Function | Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870). |
Cellular Location | Nucleus. Cytoplasm. Cell membrane Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin- dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870). |
Tissue Location | Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands.
References
Heinrich, C., et al. Oncogene 29(11):1598-1610(2010)
Thomas, G., et al. Nat. Genet. 40(3):310-315(2008)
Cowland, J.B., et al. J. Leukoc. Biol. 74(3):379-388(2003)
Caudell, E.G., et al. Biochemistry 39(42):13034-13043(2000)
Creutz, C.E., et al. J. Biol. Chem. 273(3):1393-1402(1998)
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