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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CPNE3 Antibody (C-term)   

CPNE3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CPNE3 Antibody (C-term) AP16669B
    CPNE3 Antibody (C-term) (Cat. #AP16669b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CPNE3 antibody detected the CPNE3 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75131
Other Accession NP_003900.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60131 Da
Antigen Region 507-533 aa
Additional Information
Gene ID 8895
Other Names Copine-3, Copine III, CPNE3, CPN3, KIAA0636
Target/Specificity This CPNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-533 amino acids from the C-terminal region of human CPNE3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPNE3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPNE3 (HGNC:2316)
Function Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
Cellular Location Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870) Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870)
Tissue Location Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870)
Research Areas
Citations (0)

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Background

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands.

References

Heinrich, C., et al. Oncogene 29(11):1598-1610(2010)
Thomas, G., et al. Nat. Genet. 40(3):310-315(2008)
Cowland, J.B., et al. J. Leukoc. Biol. 74(3):379-388(2003)
Caudell, E.G., et al. Biochemistry 39(42):13034-13043(2000)
Creutz, C.E., et al. J. Biol. Chem. 273(3):1393-1402(1998)

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$ 295.00
$ 99.00
Cat# AP16669B
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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