ACRC Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96QF7 |
Other Accession | NP_443189.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 76112 Da |
Antigen Region | 599-628 aa |
Gene ID | 93953 |
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Other Names | Acidic repeat-containing protein, ACRC |
Target/Specificity | This ACRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-628 amino acids from the C-terminal region of human ACRC. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ACRC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GCNA (HGNC:15805) |
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Function | May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:30914427). Can resolve the topoisomerase II (TOP2A) DPCs (By similarity). |
Cellular Location | Nucleus. Nucleus, PML body. Chromosome {ECO:0000250|UniProtKB:A0A1D9BZF0}. Note=Co-localizes with SUMO2 at PML bodies in all interphase cells (PubMed:30914427). Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (By similarity). {ECO:0000250|UniProtKB:A0A1D9BZF0, ECO:0000269|PubMed:30914427} |
Tissue Location | Expressed in germ cells of the testis (at protein level) (PubMed:27718356). Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain (PubMed:11714101). Expressed throughout spermatogenesis, from spermatogonia to elongated spermatids, in normal adult testis (at protein level) (PubMed:33963445) |
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Provided below are standard protocols that you may find useful for product applications.
Background
ACRC belongs to the serine-aspartate repeat-containing protein (SDr) family. It is detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain.
References
Kimura, K., et al. Genome Res. 16(1):55-65(2006)
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
Nolte, D., et al. Neurogenetics 3(4):207-213(2001)
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