|Application ||WB, E|
|Other Accession||NP_037438.2, NP_680086.2|
|Calculated MW||38291 Da|
|Antigen Region||223-251 aa|
|Other Names||Sorting nexin-15, SNX15|
|Target/Specificity||This SNX15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the C-terminal region of human SNX15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNX15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms. [provided by RefSeq].
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
Phillips, S.A., et al. J. Biol. Chem. 276(7):5074-5084(2001)
Barr, V.A., et al. Traffic 1(11):904-916(2000)
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