|Application ||WB, E|
|Calculated MW||76827 Da|
|Antigen Region||1-30 aa|
|Other Names||Peroxisomal acyl-coenzyme A oxidase 2, 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase, 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase, Trihydroxycoprostanoyl-CoA oxidase, THCA-CoA oxidase, THCCox, ACOX2|
|Target/Specificity||This ACOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ACOX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACOX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.|
|Tissue Location||Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Wanders, R.J., et al. Annu. Rev. Biochem. 75, 295-332 (2006) :
Moghrabi, N.N., et al. Biochem. Biophys. Res. Commun. 231(3):767-769(1997)
Baumgart, E., et al. Ann. N. Y. Acad. Sci. 804, 678-679 (1996) :
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