|Application ||WB, E|
|Calculated MW||59619 Da|
|Antigen Region||476-503 aa|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 17, USP17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, USP17L2|
|Target/Specificity||This USP17L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-503 amino acids from the C-terminal region of human USP17L2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||USP17L2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.|
|Cellular Location||Nucleus. Endoplasmic reticulum|
|Tissue Location||Broadly expressed.|
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Provided below are standard protocols that you may find useful for product applications.
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.
Pereg, Y., et al. Nat. Cell Biol. 12(4):400-406(2010)
Alkan, C., et al. Nat. Genet. 41(10):1061-1067(2009)
Burrows, J.F., et al. J. Biol. Chem. 279(14):13993-14000(2004)
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