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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   USP17L2 Antibody (C-term)   

USP17L2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - USP17L2 Antibody (C-term) AP16721b
    USP17L2 Antibody (C-term) (Cat. #AP16721b) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the USP17L2 antibody detected the USP17L2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6R6M4
Other Accession NP_958804.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59619 Da
Antigen Region 476-503 aa
Additional Information
Gene ID 377630
Other Names Ubiquitin carboxyl-terminal hydrolase 17, USP17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, USP17L2
Target/Specificity This USP17L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-503 amino acids from the C-terminal region of human USP17L2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUSP17L2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP17L2
Function Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.
Cellular Location Nucleus. Endoplasmic reticulum.
Tissue Location Broadly expressed.
Research Areas
Citations (0)

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DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.


Pereg, Y., et al. Nat. Cell Biol. 12(4):400-406(2010)
Alkan, C., et al. Nat. Genet. 41(10):1061-1067(2009)
Burrows, J.F., et al. J. Biol. Chem. 279(14):13993-14000(2004)

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Cat# AP16721b
(40 western blots)
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