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APPBP2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92624 |
| Other Accession | A5HK05, Q9DAX9, NP_006371.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66853 Da |
| Antigen Region | 243-271 aa |
| Gene ID | 10513 |
|---|---|
| Other Names | Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2, APP-BP2, Protein interacting with APP tail 1, APPBP2, KIAA0228, PAT1 |
| Target/Specificity | This APPBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids from the Central region of human APPBP2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APPBP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APPBP2 {ECO:0000303|PubMed:26138980, ECO:0000312|HGNC:HGNC:622} |
|---|---|
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa- Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (PubMed:26138980). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (PubMed:9843960). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Associated with membranes and microtubules. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.
References
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Benboudjema, L., et al. J. Virol. 77(17):9192-9203(2003)
Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14979-14984(2001)
Monni, O., et al. Proc. Natl. Acad. Sci. U.S.A. 98(10):5711-5716(2001)
Barlund, M., et al. Cancer Res. 60(19):5340-5344(2000)
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