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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ZNRF1 Antibody (Center)   

ZNRF1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ZNRF1 Antibody (Center) AP16755c
    ZNRF1 Antibody (Center) (Cat. #AP16755c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZNRF1 antibody detected the ZNRF1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8ND25
Other Accession Q91V17, NP_115644.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23783 Da
Antigen Region 59-86 aa
Additional Information
Gene ID 84937
Other Names E3 ubiquitin-protein ligase ZNRF1, 632-, Nerve injury-induced gene 283 protein, Zinc/RING finger protein 1, ZNRF1, NIN283
Target/Specificity This ZNRF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the Central region of human ZNRF1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZNRF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNRF1
Synonyms NIN283
Function E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Cellular Location Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Associated with synaptic vesicle membranes in neurons
Tissue Location Expressed primarily in the nervous system, with expression higher in developing brain relative to adult Expressed at low levels in testis and thymus
Research Areas
Citations (0)

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In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene. [provided by RefSeq].


Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Yoshida, K., et al. Biochem. Biophys. Res. Commun. 389(3):506-511(2009)
Markson, G., et al. Genome Res. 19(10):1905-1911(2009)
van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :
Araki, T., et al. J. Neurosci. 23(28):9385-9394(2003)

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$ 295.00
$ 99.00
Cat# AP16755c
(40 western blots)
Availability: In Stock
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