|Application ||WB, E|
|Other Accession||Q5XIL8, Q8C0M8, Q32KS2, NP_036276.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||79283 Da|
|Antigen Region||92-120 aa|
|Other Names||Dynein intermediate chain 1, axonemal, Axonemal dynein intermediate chain 1, DNAI1|
|Target/Specificity||This DNAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the N-terminal region of human DNAI1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNAI1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the dynein complex of respiratory cilia.|
|Cellular Location||Cytoplasm, cytoskeleton, cilium axoneme.|
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Provided below are standard protocols that you may find useful for product applications.
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Leigh, M.W., et al. Curr. Opin. Pediatr. 21(3):320-325(2009)
Zuccarello, D., et al. Hum. Reprod. 23(8):1957-1962(2008)
Failly, M., et al. Respiration 76(2):198-204(2008)
Zariwala, M.A., et al. Am. J. Respir. Crit. Care Med. 174(8):858-866(2006)
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