|Application ||WB, E|
|Other Accession||Q5ZJS6, Q3ZC67, NP_057564.3, NP_001028284.1|
|Calculated MW||14984 Da|
|Antigen Region||7-34 aa|
|Other Names||Polyadenylate-binding protein-interacting protein 2, PABP-interacting protein 2, PAIP-2, Poly(A)-binding protein-interacting protein 2, PAIP2, PAIP2A|
|Target/Specificity||This PAIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human PAIP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAIP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.|
|Tissue Location||Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.|
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Provided below are standard protocols that you may find useful for product applications.
PAIP2 acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Berlanga, J.J., et al. RNA 12(8):1556-1568(2006)
Yoshida, M., et al. EMBO J. 25(9):1934-1944(2006)
Onesto, C., et al. J. Biol. Chem. 279(33):34217-34226(2004)
Gouyon, F., et al. Biochem. J. 375 (PT 1), 167-174 (2003) :
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