|Application ||WB, E|
|Other Accession||NP_001180230.1, NP_001180229.1|
|Calculated MW||83574 Da|
|Antigen Region||151-180 aa|
|Other Names||Semaphorin-4A, Semaphorin-B, Sema B, SEMA4A, SEMAB, SEMB|
|Target/Specificity||This SEMA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human SEMA4A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEMA4A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Schmidt-Kastner, R., et al. Mol. Vis. 14, 125-135 (2008) :
Toyofuku, T., et al. EMBO J. 26(5):1373-1384(2007)
Abid, A., et al. J. Med. Genet. 43(4):378-381(2006)
Kumanogoh, A., et al. J. Cell. Sci. 116 (PT 17), 3463-3470 (2003) :
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