|Application ||WB, E|
|Other Accession||P47824, P51576, NP_002549.1|
|Calculated MW||44980 Da|
|Antigen Region||345-372 aa|
|Other Names||P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor, P2RX1, P2X1|
|Target/Specificity||This P2RX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-372 amino acids from the C-terminal region of human P2RX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2RX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)
Harper, M.T., et al. J. Thromb. Haemost. 8(7):1604-1613(2010)
Lalo, U., et al. J. Neurochem. 113(5):1177-1187(2010)
Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :
Corriden, R., et al. Sci Signal 3 (104), RE1 (2010) :
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