|Application ||WB, E|
|Other Accession||Q63054, P97411, NP_071682.1, NP_001129492.1|
|Calculated MW||54645 Da|
|Antigen Region||84-111 aa|
|Other Names||Islet cell autoantigen 1, 69 kDa islet cell autoantigen, ICA69, Islet cell autoantigen p69, ICAp69, p69, ICA1|
|Target/Specificity||This ICA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the N-terminal region of human ICA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ICA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in neurotransmitter secretion.|
|Cellular Location||Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules|
|Tissue Location||Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Buffa, L., et al. Eur. J. Cell Biol. 87(4):197-209(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Gordon, T.P., et al. Lupus 13(6):483-484(2004)
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