|Application ||WB, E|
|Calculated MW||36550 Da|
|Antigen Region||208-235 aa|
|Other Names||Taste receptor type 2 member 7, T2R7, Taste receptor family B member 4, TRB4, TAS2R7|
|Target/Specificity||This TAS2R7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-235 amino acids from the C-terminal region of human TAS2R7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAS2R7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.
Go, Y., et al. Genetics 170(1):313-326(2005)
Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)
Zhang, Y., et al. Cell 112(3):293-301(2003)
Montmayeur, J.P., et al. Curr. Opin. Neurobiol. 12(4):366-371(2002)
Margolskee, R.F. J. Biol. Chem. 277(1):1-4(2002)
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