|Application ||WB, E|
|Other Accession||P97464, Q9JK82, A5D7I4, NP_000118.2|
|Predicted||Bovine, Hamster, Mouse|
|Calculated MW||86255 Da|
|Antigen Region||298-326 aa|
|Other Names||Exostosin-1, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 1, Putative tumor suppressor protein EXT1, EXT1|
|Target/Specificity||This EXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-326 amino acids from the Central region of human EXT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EXT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq].
Zuntini, M., et al. Oncogene 29(26):3827-3834(2010)
Wen, W., et al. Genet Test Mol Biomarkers 14(3):371-376(2010)
Li, Y., et al. Pathology 42(1):91-93(2010)
Baasanjav, S., et al. BMC Med. Genet. 11, 110 (2010) :
Ludecke, H.J., et al. Genomics 40(2):351-354(1997)
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