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EXT1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EXT1 Antibody (Center) AP16833c
    EXT1 Antibody (Center) (Cat. #AP16833c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the EXT1 antibody detected the EXT1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16394
Other Accession P97464, Q9JK82, A5D7I4, NP_000118.2
Reactivity Human
Predicted Bovine, Hamster, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 86255 Da
Antigen Region 298-326 aa
Additional Information
Gene ID 2131
Other Names Exostosin-1, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 1, Putative tumor suppressor protein EXT1, EXT1
Target/Specificity This EXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-326 amino acids from the Central region of human EXT1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEXT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EXT1
Function Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.
Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq].


Zuntini, M., et al. Oncogene 29(26):3827-3834(2010)
Wen, W., et al. Genet Test Mol Biomarkers 14(3):371-376(2010)
Li, Y., et al. Pathology 42(1):91-93(2010)
Baasanjav, S., et al. BMC Med. Genet. 11, 110 (2010) :
Ludecke, H.J., et al. Genomics 40(2):351-354(1997)

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Cat# AP16833c
(40 western blots)
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