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CPNE6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95741 |
| Other Accession | NP_006023.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61991 Da |
| Antigen Region | 138-166 aa |
| Gene ID | 9362 |
|---|---|
| Other Names | Copine-6, Copine VI, Neuronal-copine, N-copine, CPNE6 |
| Target/Specificity | This CPNE6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the N-terminal region of human CPNE6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPNE6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPNE6 (HGNC:2319) |
|---|---|
| Function | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9Z140}. Cell membrane {ECO:0000250|UniProtKB:Q9Z140}. Endosome {ECO:0000250|UniProtKB:Q9Z140}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9Z140}. Perikaryon {ECO:0000250|UniProtKB:Q9Z140}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z140}. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner {ECO:0000250|UniProtKB:Q9Z140} |
| Tissue Location | Widely expressed in the brain (PubMed:9645480, PubMed:10403379, PubMed:12949241). Expressed weakly in the kidney, liver and fetal heart (PubMed:12949241). Expressed in melanocytes (PubMed:23999003). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.
References
Caudell, E.G., et al. Biochemistry 39(42):13034-13043(2000)
Nakayama, T., et al. FEBS Lett. 453 (1-2), 77-80 (1999) :
Nakayama, T., et al. J. Neurochem. 72(1):373-379(1999)
Nakayama, T., et al. FEBS Lett. 428 (1-2), 80-84 (1998) :
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