|Application ||WB, E|
|Other Accession||NP_996821.1, NP_996823.1|
|Calculated MW||26131 Da|
|Antigen Region||137-164 aa|
|Other Names||Membrane-spanning 4-domains subfamily A member 7, CD20 antigen-like 4, CD20/FC-epsilon-RI-beta family member 4, Four-span transmembrane protein 2, MS4A7, 4SPAN2, CD20L4, CFFM4|
|Target/Specificity||This MS4A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-164 amino acids from the Central region of human MS4A7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MS4A7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||4SPAN2, CD20L4, CFFM4|
|Function||May be involved in signal transduction as a component of a multimeric receptor complex.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Gingras, M.C., et al. Immunogenetics 53(6):468-476(2001)
Liang, Y., et al. Immunogenetics 53(5):357-368(2001)
Liang, Y., et al. Genomics 72(2):119-127(2001)
Ishibashi, K., et al. Gene 264(1):87-93(2001)
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