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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   FKBP6 Antibody (C-term)   

FKBP6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FKBP6 Antibody (C-term) AP16950b
    FKBP6 Antibody (C-term) (Cat. #AP16950b) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the FKBP6 antibody detected the FKBP6 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75344
Other Accession NP_003593.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37214 Da
Antigen Region 256-284 aa
Additional Information
Gene ID 8468
Other Names Inactive peptidyl-prolyl cis-trans isomerase FKBP6, Inactive PPIase FKBP6, 36 kDa FK506-binding protein, 36 kDa FKBP, FKBP-36, FK506-binding protein 6, FKBP-6, Immunophilin FKBP36, FKBP6, FKBP36
Target/Specificity This FKBP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-284 amino acids from the C-terminal region of human FKBP6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFKBP6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKBP6
Synonyms FKBP36
Function Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Cellular Location Cytoplasm, cytosol. Nucleus. Chromosome. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).
Tissue Location Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein may have cis-trans prolyl isomerase activity, and binds to clathrin heavy chain and heat shock protein 72. This gene is found to be deleted in Williams syndrome, and the orthologous gene in mouse is essential for fertility and homologous pairing in male meiosis.


Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Jarczowski, F., et al. J. Biol. Chem. 284(2):766-773(2009)
Jarczowski, F., et al. Biochemistry 47(26):6946-6952(2008)
Zhang, W., et al. Reproduction 133(2):511-516(2007)
Miyamato, T., et al. Cell. Mol. Biol. Lett. 11(4):557-569(2006)

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$ 295.00
$ 99.00
Cat# AP16950b
(40 western blots)
Availability: In Stock
Bulk Size
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