|Application ||WB, E|
|Calculated MW||37214 Da|
|Antigen Region||256-284 aa|
|Other Names||Inactive peptidyl-prolyl cis-trans isomerase FKBP6, Inactive PPIase FKBP6, 36 kDa FK506-binding protein, 36 kDa FKBP, FKBP-36, FK506-binding protein 6, FKBP-6, Immunophilin FKBP36, FKBP6, FKBP36|
|Target/Specificity||This FKBP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-284 amino acids from the C-terminal region of human FKBP6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FKBP6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Chromosome. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).|
|Tissue Location||Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein may have cis-trans prolyl isomerase activity, and binds to clathrin heavy chain and heat shock protein 72. This gene is found to be deleted in Williams syndrome, and the orthologous gene in mouse is essential for fertility and homologous pairing in male meiosis.
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Jarczowski, F., et al. J. Biol. Chem. 284(2):766-773(2009)
Jarczowski, F., et al. Biochemistry 47(26):6946-6952(2008)
Zhang, W., et al. Reproduction 133(2):511-516(2007)
Miyamato, T., et al. Cell. Mol. Biol. Lett. 11(4):557-569(2006)
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