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MRPL39 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NYK5 |
| Other Accession | NP_059142.2, NP_542984.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38712 Da |
| Antigen Region | 302-330 aa |
| Gene ID | 54148 |
|---|---|
| Other Names | 39S ribosomal protein L39, mitochondrial, L39mt, MRP-L39, 39S ribosomal protein L5, mitochondrial, L5mt, MRP-L5, MRPL39, C21orf92, MRPL5, RPML5 |
| Target/Specificity | This MRPL39 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human MRPL39. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MRPL39 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MRPL39 |
|---|---|
| Synonyms | C21orf92, MRPL5, RPML5 |
| Cellular Location | Mitochondrion |
| Tissue Location | Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.
References
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Zhang, Z., et al. Genomics 81(5):468-480(2003)
O'Brien, T.W. Gene 286(1):73-79(2002)
Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :
Spirina, O., et al. Gene 261(2):229-234(2000)
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