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RIMBP3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UFD9 |
| Other Accession | A6NJZ7, A6NNM3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 180717 Da |
| Antigen Region | 180-209 aa |
| Gene ID | 85376 |
|---|---|
| Other Names | RIMS-binding protein 3A, RIM-BP3A, RIMS-binding protein 31, RIM-BP31, RIMBP3, KIAA1666, RIMBP3A |
| Target/Specificity | This RIMBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-209 amino acids from the N-terminal region of human RIMBP3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RIMBP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RIMBP3 |
|---|---|
| Synonyms | KIAA1666, RIMBP3A |
| Function | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3V0F0}. Note=In elongating spermatids, localizes to the manchette. {ECO:0000250|UniProtKB:Q3V0F0} |
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Provided below are standard protocols that you may find useful for product applications.
Background
RIM-binding proteins (RIMBPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. RIMBP3 has been identified as a novel manchette-associated protein, and three members of RIMBP3 are known to exist: RIMBP3A, RIMBP3B and RIMBP3C. Each form of RIMBP3 exists as a large multidomain protein encoding three SH3-domains and two to three fibronectin III repeats. RIMBP3 plays a role in spermatid development and is required for normal sperm morphology and male fertility. RIMBP3 is found at high levels outside of the nervous system, with especially high expression in testis. RIMBP3C (RIMS binding protein 3C), also known as RIMBP3.3, or RIM-BP3.3, is a 1545 amino acid protein.
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