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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SIPA1 Antibody (C-term)   

SIPA1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SIPA1 Antibody (C-term) AP16989B
    SIPA1 Antibody (C-term) (Cat. #AP16989b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SIPA1 antibody detected the SIPA1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96FS4
Other Accession NP_006738.3, NP_694985.29
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 112149 Da
Antigen Region 942-970 aa
Additional Information
Gene ID 6494
Other Names Signal-induced proliferation-associated protein 1, Sipa-1, GTPase-activating protein Spa-1, p130 SPA-1, SIPA1, SPA1
Target/Specificity This SIPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 942-970 amino acids from the C-terminal region of human SIPA1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIPA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIPA1
Synonyms SPA1
Function GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
Cellular Location Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region
Tissue Location Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord
Research Areas
Citations (0)

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The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Brooks, R., et al. Gynecol. Oncol. 116(3):539-543(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Hsieh, S.M., et al. Breast Cancer Res. 11 (5), R75 (2009) :

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$ 295.00
$ 99.00
Cat# AP16989B
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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