|Application ||WB, E|
|Other Accession||NP_006738.3, NP_694985.29|
|Calculated MW||112149 Da|
|Antigen Region||942-970 aa|
|Other Names||Signal-induced proliferation-associated protein 1, Sipa-1, GTPase-activating protein Spa-1, p130 SPA-1, SIPA1, SPA1|
|Target/Specificity||This SIPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 942-970 amino acids from the C-terminal region of human SIPA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIPA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, perinuclear region Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.|
|Tissue Location||Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Brooks, R., et al. Gynecol. Oncol. 116(3):539-543(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Hsieh, S.M., et al. Breast Cancer Res. 11 (5), R75 (2009) :
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