|Application ||WB, E|
|Other Accession||Q3SZC6, NP_006392.1, Q6A1I3|
|Calculated MW||28788 Da|
|Antigen Region||17-45 aa|
|Other Names||Acidic leucine-rich nuclear phosphoprotein 32 family member B, Acidic protein rich in leucines, Putative HLA-DR-associated protein I-2, PHAPI2, Silver-stainable protein SSP29, ANP32B, APRIL, PHAPI2|
|Target/Specificity||This ANP32B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human ANP32B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANP32B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.|
|Cellular Location||Isoform 1: Nucleus. Note=Accumulates in the nuclei at the S phase.|
|Tissue Location||Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.|
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Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity).
Tochio, N., et al. J. Mol. Biol. 401(1):97-114(2010)
Shen, S.M., et al. Carcinogenesis 31(3):419-426(2010)
Chemnitz, J., et al. Eur. J. Immunol. 39(1):267-279(2009)
Munemasa, Y., et al. Mol. Cell. Biol. 28(3):1171-1181(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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