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GPR120 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GPR120 Antibody (Center) AP17024c
    GPR120 Antibody (Center) (Cat. #AP17024c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the GPR120 antibody detected the GPR120 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q5NUL3
Other Accession NP_859529.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42241 Da
Antigen Region 231-260 aa
Additional Information
Gene ID 338557
Other Names Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, Omega-3 fatty acid receptor 1, FFAR4, GPR120, GPR129, O3FAR1, PGR4
Target/Specificity This GPR120 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the Central region of human GPR120.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPR120 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FFAR4
Synonyms GPR120, GPR129, O3FAR1, PGR4
Function Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Colocalized with ARRB2 following DHA treatment.
Tissue Location Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas
Research Areas
Citations (0)

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Background

GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).

References

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Burns, R.N., et al. Biochem. Biophys. Res. Commun. 396(4):1030-1035(2010)
Moore, K., et al. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 154(4):419-426(2009)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Hirasawa, A., et al. Nat. Med. 11(1):90-94(2005)

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Cat# AP17024c
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Quantity:
(40 western blots)
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