|Application ||WB, E|
|Calculated MW||42241 Da|
|Antigen Region||231-260 aa|
|Other Names||Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, Omega-3 fatty acid receptor 1, FFAR4, GPR120, GPR129, O3FAR1, PGR4|
|Target/Specificity||This GPR120 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the Central region of human GPR120.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR120 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR120, GPR129, O3FAR1, PGR4|
|Function||Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Colocalized with ARRB2 following DHA treatment.|
|Tissue Location||Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Burns, R.N., et al. Biochem. Biophys. Res. Commun. 396(4):1030-1035(2010)
Moore, K., et al. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 154(4):419-426(2009)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Hirasawa, A., et al. Nat. Med. 11(1):90-94(2005)
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