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ESR2 Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP1702c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ESR2 Antibody (Center) - Product info | |
| Application | WB, FC
|
| Primary Accession | Q92731 |
| Other Accession | Q62986, Q9XSW2, Q9PTU5, Q9XSB5 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Chicken, Pig, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 59216 Da |
ESR2 Antibody (Center) - Additional info | |
| Gene ID 2100 | |
| Other Names ESR2; ESTRB; NR3A2; Estrogen receptor beta; Nuclear receptor subfamily 3 group A member 2 | |
| Target/Specificity This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376~405 amino acids from the Center region of human ESR2. | |
| Dilution WB~~1:1000WB~~1:1000 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ESR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ESR2 Antibody (Center) - Protein Information | |
| Name ESR2 | |
| Synonyms ESTRB, NR3A2 | |
| Function Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual | |
| Cellular Location Nucleus. | |
| Tissue Location Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain | |
ESR2 Antibody (Center) - Related products
AP1702c: ESR2 Antibody (Center)
BP1702c: ESR2 Antibody (Center) Blocking Peptide
ESR2 Antibody (Center) - Application data
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ESR2 Antibody (Center) (Cat. #AP1702c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ESR2 antibody detected the ESR2 protein (arrow).
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Flow cytometric analysis of HepG2 cells using ESR2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ESR2 Antibody (Center) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ESR2 is a nuclear hormone receptor. The protein binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
REFERENCES
Chen H., Lin R.J.Cell 90:569-580(1997) Caira F., Antonson P.J. Biol. Chem. 275:5308-5317(2000) Bu H., Kashireddy P.Biochem. Biophys. Res. Commun. 317:54-59(2004)
