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NCAPG2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86XI2 |
| Other Accession | NP_060230.5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 130960 Da |
| Antigen Region | 729-757 aa |
| Gene ID | 54892 |
|---|---|
| Other Names | Condensin-2 complex subunit G2, Chromosome-associated protein G2, CAP-G2, hCAP-G2, Leucine zipper protein 5, Non-SMC condensin II complex subunit G2, NCAPG2, LUZP5 |
| Target/Specificity | This NCAPG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 729-757 amino acids from the Central region of human NCAPG2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NCAPG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCAPG2 |
|---|---|
| Synonyms | LUZP5 |
| Function | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPG2 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).
References
Wood, J.L., et al. J. Biol. Chem. 283(43):29586-29592(2008)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
Smith, E.D., et al. Mol. Cell. Biol. 24(3):1168-1173(2004)
Ono, T., et al. Cell 115(1):109-121(2003)
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