IFIT2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P09913 |
Other Accession | NP_001538.4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54632 Da |
Antigen Region | 307-335 aa |
Gene ID | 3433 |
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Other Names | Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54 |
Target/Specificity | This IFIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the Central region of human IFIT2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | IFIT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IFIT2 |
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Synonyms | CIG-42, G10P2, IFI54, ISG54 |
Function | IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. |
Cellular Location | Cytoplasm. Endoplasmic reticulum |
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Provided below are standard protocols that you may find useful for product applications.
References
Lai, K.C., et al. Mol. Cancer Res. 6(9):1431-1439(2008)
Terenzi, F., et al. J. Biol. Chem. 281(45):34064-34071(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Saha, S., et al. J. Gen. Virol. 87 (PT 11), 3285-3289 (2006) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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