|Application ||WB, E|
|Calculated MW||54632 Da|
|Antigen Region||307-335 aa|
|Other Names||Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54|
|Target/Specificity||This IFIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the Central region of human IFIT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFIT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CIG-42, G10P2, IFI54, ISG54|
|Function||IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Lai, K.C., et al. Mol. Cancer Res. 6(9):1431-1439(2008)
Terenzi, F., et al. J. Biol. Chem. 281(45):34064-34071(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Saha, S., et al. J. Gen. Virol. 87 (PT 11), 3285-3289 (2006) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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