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IFIT2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IFIT2 Antibody (Center) AP17102c
    IFIT2 Antibody (Center) (Cat. #AP17102c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the IFIT2 antibody detected the IFIT2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09913
Other Accession NP_001538.4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54632 Da
Antigen Region 307-335 aa
Additional Information
Gene ID 3433
Other Names Interferon-induced protein with tetratricopeptide repeats 2, IFIT-2, ISG-54 K, Interferon-induced 54 kDa protein, IFI-54K, P54, IFIT2, CIG-42, G10P2, IFI54, ISG54
Target/Specificity This IFIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the Central region of human IFIT2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFIT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFIT2
Synonyms CIG-42, G10P2, IFI54, ISG54
Function IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Cellular Location Cytoplasm. Endoplasmic reticulum
Research Areas
Citations (0)

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Lai, K.C., et al. Mol. Cancer Res. 6(9):1431-1439(2008)
Terenzi, F., et al. J. Biol. Chem. 281(45):34064-34071(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Saha, S., et al. J. Gen. Virol. 87 (PT 11), 3285-3289 (2006) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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$ 295.00
$ 99.00
Cat# AP17102c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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