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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TPBG Antibody (Center)   

TPBG Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TPBG Antibody (Center) AP17116c
    TPBG Antibody (Center) (Cat. #AP17116c) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the TPBG antibody detected the TPBG protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13641
Other Accession NP_001159864.1, NP_006661.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46032 Da
Antigen Region 169-197 aa
Additional Information
Gene ID 7162
Other Names Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1, TPBG, 5T4
Target/Specificity This TPBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the Central region of human TPBG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTPBG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms 5T4
Function May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma
Research Areas
Citations (0)

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This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq].


Elkord, E., et al. J. Immunother. 31(9):820-829(2008)
Shingler, W.H., et al. Int. Immunol. 20(8):1057-1066(2008)
Okazaki, S., et al. Obstet Gynecol 110(5):1130-1136(2007)
Ward, C.M., et al. Exp. Cell Res. 312(10):1713-1726(2006)
Mulryan, K., et al. Mol. Cancer Ther. 1(12):1129-1137(2002)

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Cat# AP17116c
(40 western blots)
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