|Application ||WB, E|
|Other Accession||NP_060705.2, NP_001161971.1|
|Calculated MW||52878 Da|
|Antigen Region||348-375 aa|
|Other Names||Cytosolic non-specific dipeptidase, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2, CN2, CPGL, PEPA|
|Target/Specificity||This CNDP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-375 amino acids from the C-terminal region of human CNDP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNDP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CN2, CPGL, PEPA|
|Function||Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.|
|Tissue Location||Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CNDP2, also known as tissue carnosinase and peptidase A (EC 220.127.116.11), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).
Ahmed, A.H., et al. Biochemistry 49(13):2843-2850(2010)
McDonough, C.W., et al. Hum. Genet. 126(2):265-275(2009)
Wanic, K., et al. Diabetes 57(9):2547-2551(2008)
Wanic, K., et al. Diabetes (2008) In press :
Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
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