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ACACA Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP17139b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP17139b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ACACA Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q13085 |
| Other Accession | P11497, Q5SWU9, Q9TTS3, NP_942133.1, NP_942131.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 265554 Da |
ACACA Antibody (C-term) - Additional info | |
| Gene ID 31 | |
| Other Names ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC-alpha; Biotin carboxylase | |
| Target/Specificity This ACACA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2009-2039 amino acids from the C-terminal region of human ACACA. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACACA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACACA Antibody (C-term) - Protein Information | |
| Name ACACA | |
| Synonyms ACAC, ACC1, ACCA | |
| Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | |
| Cellular Location Cytoplasm. | |
| Tissue Location Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver | |
ACACA Antibody (C-term) - Related products
AP17139b: ACACA Antibody (C-term)
RI10039: ACACA predesign siRNA
AT1018a: ACACA Antibody (monoclonal) (M01)
ACACA Antibody (C-term) - Application data
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ACACA Antibody (C-term) (Cat. #AP17139b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ACACA antibody detected the ACACA protein (arrow).
ACACA Antibody (C-term) - Research Areas
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BACKGROUND
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010) Zhao, L.F., et al. Endocr. J. 57(4):317-324(2010)
