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CBX2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CBX2 Antibody (Center) AP17146c
    CBX2 Antibody (Center) (Cat. #AP17146c) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the CBX2 antibody detected the CBX2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14781
Other Accession P30658, NP_005180.1, NP_116036.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 56081 Da
Antigen Region 137-166 aa
Additional Information
Gene ID 84733
Other Names Chromobox protein homolog 2, CBX2
Target/Specificity This CBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of human CBX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX2
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.
Cellular Location Nucleus.
Citations (0)

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This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.


Biason-Lauber, A., et al. Am. J. Hum. Genet. 84(5):658-663(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Agrawal, N., et al. PLoS ONE 3 (12), E4032 (2008) :
Garcia, E., et al. EMBO J. 18(12):3404-3418(1999)
Katoh-Fukui, Y., et al. Nature 393(6686):688-692(1998)

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$ 295.00
$ 99.00
Cat# AP17146c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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