|Application ||WB, E|
|Other Accession||P30658, NP_005180.1, NP_116036.1|
|Calculated MW||56081 Da|
|Antigen Region||137-166 aa|
|Other Names||Chromobox protein homolog 2, CBX2|
|Target/Specificity||This CBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of human CBX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Biason-Lauber, A., et al. Am. J. Hum. Genet. 84(5):658-663(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Agrawal, N., et al. PLoS ONE 3 (12), E4032 (2008) :
Garcia, E., et al. EMBO J. 18(12):3404-3418(1999)
Katoh-Fukui, Y., et al. Nature 393(6686):688-692(1998)
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