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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CLCN3 Antibody (Center)   

CLCN3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CLCN3 Antibody (Center) AP17154c
    CLCN3 Antibody (Center) (Cat. #AP17154c) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CLCN3 antibody detected the CLCN3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P51790
Other Accession P51792, O18894, P51791, NP_776297.2, NP_001820.2
Reactivity Human
Predicted Mouse, Rabbit, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 90966 Da
Antigen Region 285-313 aa
Additional Information
Gene ID 1182
Other Names H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3, CLCN3
Target/Specificity This CLCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-313 amino acids from the Central region of human CLCN3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLCN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLCN3
Function Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
Cellular Location Isoform 1: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P51791}; Multi-pass membrane protein. Note=Isoform 1 is localized mainly in late endosomes.
Tissue Location Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).
Research Areas
Citations (0)

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Background

CLCN3 mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.

References

Cuddapah, V.A., et al. J. Biol. Chem. 285(15):11188-11196(2010)
Xiong, D., et al. Clin. Exp. Pharmacol. Physiol. 36(4):386-393(2009)
Yin, Z., et al. Am. J. Physiol., Cell Physiol. 294 (2), C535-C542 (2008) :
Matsuda, J.J., et al. Am. J. Physiol., Cell Physiol. 294 (1), C251-C262 (2008) :
Kasinathan, R.S., et al. FEBS Lett. 581(28):5407-5412(2007)

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$ 295.00
$ 99.00
Cat# AP17154c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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