|Application ||WB, E|
|Other Accession||NP_001158230.1, NP_001158231.1|
|Calculated MW||43073 Da|
|Antigen Region||55-84 aa|
|Other Names||cAMP-dependent protein kinase type I-beta regulatory subunit, PRKAR1B|
|Target/Specificity||This PRKAR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human PRKAR1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRKAR1B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.|
|Cellular Location||Cell membrane.|
|Tissue Location||Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.[supplied by OMIM].
Silva, L.K., et al. Eur. J. Hum. Genet. (2010) In press :
Liu, Y.J., et al. Obesity (Silver Spring) (2010) In press :
Zhan, X., et al. Anal. Biochem. 354(2):279-289(2006)
Gullingsrud, J., et al. Structure 14(1):141-149(2006)
Zhang, L., et al. Mol. Cell. Biol. 24(5):2169-2180(2004)
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