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NR3C2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NR3C2 Antibody (Center) AP17202c
    NR3C2 Antibody (Center) (Cat. #AP17202c) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the NR3C2 antibody detected the NR3C2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08235
Other Accession Q91573, P22199, Q8VII8, NP_000892.2
Reactivity Human
Predicted Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 107067 Da
Antigen Region 654-683 aa
Additional Information
Gene ID 4306
Other Names Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2, NR3C2, MCR, MLR
Target/Specificity This NR3C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the Central region of human NR3C2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNR3C2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR3C2
Synonyms MCR, MLR
Function Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Cellular Location Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane
Tissue Location Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes
Research Areas
Citations (0)

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This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.


van Leeuwen, N., et al. Hypertension 56(5):995-1002(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bouma, E.M., et al. Behav. Genet. (2010) In press :
Bogdan, R., et al. Genes Brain Behav. 9(6):658-667(2010)
Gu, D., et al. J. Hypertens. 28(6):1210-1220(2010)

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$ 295.00
$ 99.00
Cat# AP17202c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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