|Application ||WB, E|
|Other Accession||Q91573, P22199, Q8VII8, NP_000892.2|
|Predicted||Mouse, Rat, Xenopus|
|Calculated MW||107067 Da|
|Antigen Region||654-683 aa|
|Other Names||Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2, NR3C2, MCR, MLR|
|Target/Specificity||This NR3C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the Central region of human NR3C2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NR3C2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.|
|Cellular Location||Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane|
|Tissue Location||Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
van Leeuwen, N., et al. Hypertension 56(5):995-1002(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bouma, E.M., et al. Behav. Genet. (2010) In press :
Bogdan, R., et al. Genes Brain Behav. 9(6):658-667(2010)
Gu, D., et al. J. Hypertens. 28(6):1210-1220(2010)
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