|Application ||WB, E|
|Other Accession||NP_001121163.1, NP_057208.2|
|Calculated MW||45211 Da|
|Antigen Region||173-201 aa|
|Other Names||Blood group Rh(D) polypeptide, RHXIII, Rh polypeptide 2, RhPII, Rhesus D antigen, CD240D, RHD|
|Target/Specificity||This RHD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-201 amino acids from the Central region of human RHD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RHD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Restricted to tissues or cell lines expressing erythroid characters|
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Provided below are standard protocols that you may find useful for product applications.
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.
Flegr, J., et al. Folia Parasitol. 57(2):143-150(2010)
Liu, H.C., et al. Biochim. Biophys. Acta 1800(6):565-573(2010)
Schmid, P., et al. Transfusion 50(1):267-269(2010)
Wang, X.D., et al. Eur. J. Clin. Invest. 39(7):607-617(2009)
Wagner, F.F., et al. Blood 99(6):2272-2273(2002)
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