|Application ||WB, E|
|Calculated MW||70943 Da|
|Antigen Region||95-123 aa|
|Other Names||Heterogeneous nuclear ribonucleoprotein R, hnRNP R, HNRNPR, HNRPR|
|Target/Specificity||This HNRNPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human HNRNPR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HNRNPR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Hadian, K., et al. J. Biol. Chem. 284(48):33384-33391(2009)
Fukuda, A., et al. J. Biol. Chem. 284(35):23472-23480(2009)
Tonevitsky, E.A., et al. Bull. Exp. Biol. Med. 147(6):733-736(2009)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
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