|Application ||WB, IHC-P, E|
|Calculated MW||129172 Da|
|Antigen Region||260-291 aa|
|Other Names||BMP-2-inducible protein kinase, BIKe, BMP2K, BIKE|
|Target/Specificity||This BIKE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-291 amino acids from the Central region of human BIKE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BIKE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in osteoblast differentiation.|
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Provided below are standard protocols that you may find useful for product applications.
BIKE is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation.
Kearns, A.E., et al., J. Biol. Chem. 276(45):42213-42218 (2001).
Hoffmann, A., et al., Crit. Rev. Eukaryot. Gene Expr. 11 (1-3), 23-45 (2001).
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