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MCC Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MCC Antibody (Center) AP17244c
    MCC Antibody (Center) (Cat. #AP17244c) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the MCC antibody detected the MCC protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23508
Other Accession NP_002378.1, NP_001078846.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 93027 Da
Antigen Region 473-501 aa
Additional Information
Gene ID 4163
Other Names Colorectal mutant cancer protein, Protein MCC, MCC
Target/Specificity This MCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-501 amino acids from the Central region of human MCC.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMCC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCC
Function Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
Cellular Location Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)
Fukuyama, R., et al. Oncogene 27(46):6044-6055(2008)

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$ 295.00
$ 99.00
Cat# AP17244c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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